Overview
Main results
For each phenotype below, please click
to view network enrichment results, click
to view gene prioritization results, and click
to view gene cross-reference results. Please note that loading gene
prioritization results may take a while because of the large number of
genes displayed.
The network enrichment results
()
of each phenotype consist of RSS-NET enrichment Bayes factors of 38 inferred
gene regulatory networks and 1 near-gene control network for the
given trait, and enrichment \(P\)-values of LDSC and Pascal based on the
same networks and GWAS data.
The gene prioritization results
()
of each phenotype consist of RSS-NET posterior probabilities of
association (\(P_1\)) for all network
genes under the baseline (\(M_0\)) and
enrichment (\(M_1\)) models for the
given trait.
The gene cross-reference results
()
of each phenotype consist of external information from Therapeutic
Target Database (TTD), Mouse Genome Informatics (MGI) and Online
Mendelian Inheritance in Man (OMIM).
| Phenotype (GWAS publication) | Network enrichment | Gene prioritization | Cross reference |
|---|---|---|---|
| Adult height (Wood et al. 2014) |
|
|
N/A |
| Body mass index (Locke et al. 2015) |
|
|
|
| Waist-to-hip ratio (Shungin et al. 2015) |
|
|
|
| Breast cancer (Michailidou et al. 2013) |
|
|
|
| Rheumatoid arthritis (Okada et al. 2014) |
|
|
|
| Crohn’s disease (Liu et al. 2015) |
|
|
N/A |
| Inflammatory bowel disease (Liu et al. 2015) |
|
|
|
| Ulcerative colitis (Liu et al. 2015) |
|
|
|
| High-density lipoprotein (Teslovich et al. 2010) |
|
|
|
| Low-density lipoprotein (Teslovich et al. 2010) |
|
|
|
| Type 2 diabetes (Morris et al. 2012) |
|
|
|
| Heart rate (den Hoed et al. 2013) |
|
|
|
| Coronary artery disease (Nikpay et al. 2015) |
|
|
|
| Myocardial infarction (Nikpay et al. 2015) |
|
|
|
| Atrial fibrillation (Christophersen et al. 2017) |
|
|
|
| Alzheimer’s disease (Lambert et al. 2013) |
|
|
|
| Schizophrenia (Ripke et al. 2014) |
|
|
|
| Neuroticism (Okbay et al. 2016) |
|
|
|
Additional resources