Overview
Main results
For each phenotype below, please click 
to view network enrichment results, click 
to view gene prioritization results, and click 
to view gene cross-reference results. Please note that loading gene prioritization results may take a while because of the large number of genes displayed.
The network enrichment results () of each phenotype consist of RSS-NET enrichment Bayes factors of 38 inferred gene regulatory networks and 1 near-gene control network for the given trait, and enrichment \(P\)-values of LDSC and Pascal based on the same networks and GWAS data.
The gene prioritization results () of each phenotype consist of RSS-NET posterior probabilities of association (\(P_1\)) for all network genes under the baseline (\(M_0\)) and enrichment (\(M_1\)) models for the given trait.
The gene cross-reference results () of each phenotype consist of external information from Therapeutic Target Database (TTD), Mouse Genome Informatics (MGI) and Online Mendelian Inheritance in Man (OMIM).
| Phenotype (GWAS publication) | Network enrichment | Gene prioritization | Cross reference |
|---|---|---|---|
| Adult height (Wood et al. 2014) |
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N/A |
| Body mass index (Locke et al. 2015) |
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| Waist-to-hip ratio (Shungin et al. 2015) |
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| Breast cancer (Michailidou et al. 2013) |
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| Rheumatoid arthritis (Okada et al. 2014) |
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| Crohn’s disease (Liu et al. 2015) |
|
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N/A |
| Inflammatory bowel disease (Liu et al. 2015) |
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| Ulcerative colitis (Liu et al. 2015) |
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| High-density lipoprotein (Teslovich et al. 2010) |
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| Low-density lipoprotein (Teslovich et al. 2010) |
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| Type 2 diabetes (Morris et al. 2012) |
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| Heart rate (den Hoed et al. 2013) |
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| Coronary artery disease (Nikpay et al. 2015) |
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| Myocardial infarction (Nikpay et al. 2015) |
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| Atrial fibrillation (Christophersen et al. 2017) |
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| Alzheimer’s disease (Lambert et al. 2013) |
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| Schizophrenia (Ripke et al. 2014) |
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| Neuroticism (Okbay et al. 2016) |
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Additional resources